Animal Models 

· Partially humanized TE-stroke in mouse 

  • Mechanical occlusion stroke models (global and focal; permanent and transient) 

  • Induction of intracerebral hemorrhage in rodents (ICH; collagenase and blood models) 

  • Traumatic brain injury (TBI) model in adult rat and mouse (controlled cortical impact, CCI) 

    • Closed head pediatric TBI model  

    • Bilateral common carotid artery stenosis (BCAS) model using microcoil to induce VCID and white matter degeneration.  

    • Surgical parabiosis (for shared circulation/ blood/ humoral exchange studies) in mice 

    • Model of pediatric brain tumor  

    • Experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS) 

    • Spinal cord injury and spinal stenosis models in rats 

  • Induction of Parkinsonism in mice; 6-OHDA and MPTP models 

    · Induction of Alzheimer disease in rats (Streptozotocin model) 

  • Stereotaxic surgery in rodents (for stem cell transplantation, viral transfection etc.) 

  • Irradiation chimera and Adoptive transfer models 

  • Controlled impact model of traumatic optic neuropathy 

  • Neurobehavioral tests (for Motor, Cognitive, and Psychiatric outcomes) 

Pharmacology 

·       Pharmacokinetic (PK) and pharmacodynamic (PD) studies 

  • Compound toxicity and metabolism studies 

  • Compound efficacy and therapeutic studies (double blinded preclinical trials and testing) 

In Vivo Imaging, Recording and Routine Lab Tests 

·       Analysis of MR-imaging for absolute cerebral blood flow, edema, hematoma size, white matter content         (ASL (FAIR) RARE-imaging, T2W, MSME T2Map, MGE T2*Map, DTI) 

  • Laser speckle contrast imaging and analysis for cerebral perfusion 

  • Laser doppler flowmetry for relative cerebral blood flow 

  • Analysis of SPECT-CT imaging (such as Tc-Pyrophosphate RBC-labeling and tracking to determine RBCs pool) for cerebrovascular insufficiency. 

·       Laser-assisted ektacytometry for rheological studies of RBCs 

·       All Kind of Neurobehavioral Tests and Analyses 

·       Routine Biochemical, Molecular and Histopathological Assays and Analyses. 

·       Ozone-based chemiluminescence assay for nitric oxide and metabolites (Sievers NOA 280i). 

·       Hemoglobin-oxygen binding-dissociation assay (BloodOx-2019) 

         Routine Biochemical Assays and Analyses.